Name the site where detoxification of xenobiotic compounds takes place?
A.
Cytosol
B.
RER
C.
SER
D.
Ribosome
Answer: Option C
Explanation:
SER is smooth endoplasmic reticulum which is a part of endoplasmic reticulum membrane where ribosome is not attached. It is the major site for removal of xenobiotics, and the reaction is catalyzed by cytochrome P-450.
Name the sequence which allows the resident protein to retain in ER lumen?
A.
KDEL
B.
KKXX
C.
KLDE
D.
KXXK
Answer: Option A
Explanation:
KDEL stands for lys-asp-glu-leu sequences, present at the C-terminus of resident proteins. These sequences act as a sorting signal which is necessary for retention of protein in the ER.